Peripheral Arterial Disease (PAD): Leg Pain, Causes and Care
Peripheral arterial disease is when fatty deposits restrict blood flow to the leg muscles. This article explains symptoms, causes, tests, care and warning signs.
Educational information only, not medical advice. Always ask a qualified doctor about your own health. In an emergency call 112 (India) or 911 (US). Read the full disclaimer.
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Pain in your legs when you walk is easy to put down to age or tiredness, but sometimes it is a sign of a circulation problem. Peripheral arterial disease, or PAD, is one cause. This article explains what the NHS says about it.
What is PAD?
The NHS describes PAD as a common condition in which fatty deposits build up in the arteries and restrict the blood supply to the leg muscles. It is a form of cardiovascular disease. The NHS lists it alongside coronary heart disease, aortic disease and stroke as one of the main types of cardiovascular disease.
Symptoms
Many people have no symptoms. When symptoms occur, they usually develop slowly. The NHS lists:
- A painful ache in the legs when walking, which usually eases after a few minutes of rest. This is called intermittent claudication, and can affect one or both legs.
- Hair loss on the legs and feet
- Numbness or weakness in the legs
- Brittle, slow-growing toenails
- Ulcers on the feet or legs that do not heal
- Skin that looks paler or blue, or shiny skin
- Erectile dysfunction in men
- Wasting of the leg muscles
Causes and risk factors
The NHS says PAD is usually caused by atherosclerosis, where cholesterol-based deposits called atheroma build up in the walls of the leg arteries and narrow them. Risk factors include smoking, which it calls the most significant, type 1 or type 2 diabetes, high blood pressure, high cholesterol and older age.
How is it diagnosed?
According to the NHS, a doctor usually diagnoses PAD through a physical examination and by comparing the blood pressure in your arm with the blood pressure at your ankle. This is called the ankle brachial pressure index, and a difference between the two may point to PAD. The NHS advises having recurring leg pain during exercise checked by a doctor.
Treatment and looking after yourself
The NHS says treatment is mainly lifestyle changes and medication. Lifestyle steps include:
- Regular exercise
- Not smoking
- A healthy diet
- Losing weight if you are overweight
- Moderating alcohol
Conditions such as high blood pressure, high cholesterol and diabetes should also be treated. Medicine and, in some cases, surgery can improve blood flow to the legs. With treatment, the NHS says most people's symptoms stay stable and some people's pain improves. For critical limb ischaemia, a serious form of the condition, an angioplasty or bypass graft is usually recommended, though these may not always succeed, and amputation is needed in a few cases. Your specialist will explain which treatments suit you.
The NHS page has no section on prevention, but its advice on risk factors suggests that not smoking, being active, eating well and controlling blood pressure, cholesterol and diabetes all matter. The WHO also lists peripheral arterial disease as one of the cardiovascular diseases and names tobacco use, an unhealthy diet and inactivity among the main risk factors.
When to see a doctor
See a doctor if you get recurring leg pain when you exercise, or if you notice any of the other symptoms above, especially sores on your feet that are slow to heal. Take extra care of your feet if you have diabetes.
Contact a doctor immediately if you develop signs of critical limb ischaemia, which the NHS lists as severe burning pain in the legs or feet that continues at rest, pale, shiny, smooth, dry skin, wounds or ulcers that do not heal, loss of leg muscle, or cold, numb skin on the toes or lower legs that turns red then black, swells or produces smelly pus. The NHS says symptoms that develop quickly or suddenly worsen may need immediate treatment. If you cannot reach a doctor, call a health helpline or seek emergency care.
In an emergency, call your local emergency number (112 in India, 911 in the United States).
Common questions
What is intermittent claudication?
The NHS describes it as a painful ache in the legs when walking that usually eases after a few minutes of rest, caused by PAD.
What is the biggest risk factor for PAD?
The NHS says smoking is the most significant risk factor. Diabetes, high blood pressure, high cholesterol and older age also raise risk.
How is PAD diagnosed?
The NHS says a doctor usually uses a physical examination and compares blood pressure in the arm and ankle, called the ankle brachial pressure index.
What are signs of a serious problem?
The NHS lists severe burning pain at rest, pale shiny skin, non-healing wounds, muscle loss, and cold numb skin that turns red then black. Contact a doctor immediately.
Important: please read
- Educational information only. This article is general health education. It is not medical advice, diagnosis or treatment. Reading it does not create a doctor–patient relationship with MyDoctor or with anyone else.
- Ask a qualified doctor. Always talk to a qualified, registered doctor about your own health. In India, that means a doctor registered with the National Medical Commission (NMC) or a State Medical Council. In the United States, a licensed physician. Elsewhere, a doctor licensed where you live.
- Never ignore or delay professional advice because of something you read here. Do not start, stop or change any medicine or treatment without your doctor.
- Emergencies: call 112 in India, 911 in the United States, or your local emergency number. Do not wait for an online answer.
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- About the sources. This article summarises, in our own words, information from the public health bodies named under Sources. Health knowledge changes, and this summary may not reflect the latest research or your personal situation.
- Liability. To the extent permitted by law, MyDoctor (MODERNUS HEALTH TECHNOLOGIES PRIVATE LIMITED) accepts no liability for any decision made on the basis of this content.
Sources
- NHS. Peripheral arterial disease - NHS www.nhs.uk
- NHS. Cardiovascular disease - NHS www.nhs.uk
- WHO. Cardiovascular diseases (CVDs) fact sheet - WHO www.who.int

Dr. Ambed Mishra, PharmD, PhD
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MyDoctor by MODERN US HEALTH, Austin, Texas. Ahmedabad, Gujarat. Bangalore, India.
Dr. Ambed Mishra is a clinical (patient care) scientist, author and former professor. He is Group CEO and Chief Medical Officer of MODERN US HEALTH (MODERN US GROUP), Austin, Texas, the group behind MyDoctor, and a senior consultant who teaches and trains MD/DO physicians, PharmD and PhD professionals, nurses and other healthcare professionals in patient care in the United States and India.
More about Dr. Ambed Mishra
- More than ten years of full-time leadership in United States healthcare, building patient care services that improve medication adherence and bring doctors, pharmacists and nurses together around each patient.
- Leads the MD and engineering teams behind MyDoctor: clinic and hospital management software, electronic health records and telehealth for hospitals and physician groups in the United States and India.
- Former Assistant Professor and Clinical Preceptor at Rajiv Gandhi University of Health Sciences, Bangalore, and senior researcher with hospitals, universities and patient care groups in India and the United States.
- More than 30 published research and review articles and case reports, and more than 15 international conference presentations in India, Australia, Canada, the United States, Spain and other countries.
- Chief Medical Officer and Global Program Head of a nonprofit mission that helps cover hospital and doctor visit bills for patients in need in India, Nepal, the United States and other countries.
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